HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Dahlberg, S. T. Articles by Leppo, J. A. Search for Related Content PubMed PubMed Citation Articles by Dahlberg, S. T. Articles by Leppo, J. A.

Myocardial Extraction of Technetium-99m-[2-(1-Methoxybutyl) Isonitrile] in the Isolated Rabbit Heart: A Myocardial Perfusion Agent with High Extraction and Stable Retention

Departments of Nuclear Medicine and Medicine (Division of Cardiology), University of Massachusetts Medical Center, Worcester, Massachusetts
Department of Physiology, University of the Pacific, Stockton, California

Correspondence: For correspondence or reprints contact: Seth T. Dahlberg, MD, Department of Nuclear Medicine, University of Massachusetts Medical Center, 55 Lake Avenue North, Worcester, MA 01655.

ABSTRACT

Technetium-99m-[2-(1-methoxybutyl) isonitrile] (MBI) is a potential new compound for the scintigraphic imaging of coronary flow. Evaluation in the blood-perfused isolated rabbit heart model showed this compound to have a myocardial uptake comparable to ²⁰¹Tl and higher than sestamibi. Although the mean ± s.d. maximum extraction (E_max and capillary permeability-surface area product (PS_cap) of ^99mTc-MBI (E_max = 0.45 ± 0.10, PS_cap = 1.07 ± 0.47 ml/min · g) were much less than ²⁰¹ (E_max = 0.71 ± 0.07, PS_cap = 2.21 ± 0.76 ml/min · g, p < 0.0001), the net extraction of _99mTc-MBI (E_net = 0.52 ± 0.10) was only slightly less than the value for ²⁰¹Tl (E_net = 0.56 ± 0.10, p < 0.05). There was no significant difference in the myocardial uptake versus flow between _99mTc-MBI and ₂₀₁Tl. These data indicate that assessment of relative coronary flow based on the myocardial uptake of ^99mTc-MBI should give results comparable to ²⁰¹Tl. Therefore, _99mTc-MBI may have clinical potential as a radiolabeled myocardial perfusion agent.