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Indium-111-Leukocyte Imaging in Gaucher's Disease

Division of Nuclear Medicine, Long Island Jewish Medical Center, Medical Center, New Hyde Park, New York

Correspondence: For correspondence or reprints contact: Christopher J. Palestro, MD, Division of Nuclear Medicine, Long Island Jewish Medical Center, Lakeville Rd., New Hyde Park, NY 11042.

ABSTRACT

A 29-yr-old man with Gaucher's disease and fever of unknown origin underwent ¹¹¹ln-labeled mixed autologous leukocyte scintigraphy. Although no focus of infection was identified, the resulting images were most unusual and were characterized by massive hepatomegaly, lack of central marrow activity and extensive lymph node uptake of labeled leukocytes. All of these findings could be explained on the basis of the patient's underlying disease. Hepatomegaly and absent central marrow activity correlated with extensive infiltration of these organs by Gauchercells, while the lymphnode findings were attributed to the presence of extramedullary hematopoiesis.