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Vitamin C as a Radioprotector Against Iodine-131 In Vivo

Department of Radiology, University of Medicine and Dentistry of New Jersey, Newark New Jersey
Department of Physics and Astronomy, University of Massachusetts, Amherst, Massachusetts

Correspondence: For correspondence and reprints, contact: Dandamudi V. Rao, PhD, Dept of Radiology, Division of Radiation Research, MSB F-451, UMDNJ-New Jersey Medical School, 185 South Orange Ave., Newark, NJ 07103.

ABSTRACT

The capacity of vitamin C (ascorbic acid) to mitigate radiation damage resulting from the tissue-incorporated radionuclide ¹³¹I is examined. Spermatogenesis in mice is the experimental model and spermhead survival is the biological endpoint. When a small nontoxic amount of vitamin C was injected, followed by a similar injection of ¹³¹I, the 37% spermhead survival dose (D₃₇) increased by a factor of 2.2 compared with the D₃₇ in animals receiving only the radionuclide. Similar radioprotection was also observed when the animals were maintained on a diet enriched with 1% vitamin C (by weight). These results suggest that vitamin C may play an important role as a radioprotector against accidental or medical radiation exposures, especially when radionuclides are incorporated in the body and deliver the dose in a chronic fashion.

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