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Simultaneous Occurrence of Rib Infarction and Pulmonary Infiltrates in Sickle Cell Disease Patients with Acute Chest Syndrome

Department of Radiology, Children's Hospital Medical Center
E. L. Saenger Radioisotope Laboratory and Comprehensive Sickle Cell Center, Departments of Radiology, Pediatrics and Internal Medicine, University of Cincinnati, Cincinnati, Ohio

Correspondence: For correspondence and reprints contact: Michael J. Gelfand, MD, Section of Nuclear Medicine, Dept. of Radiology, Children's Hospital Medical Center, Cincinnati, OH 45229-2899.

ABSTRACT

In order to determine if a relationship exists between rib infarction and the acute chest syndrome (ACS) in sickle cell disease patients, bone scans were reviewed in 55 episodes in 38 patients with pain of suspected osseous origin. A bone scan was positive for thoracic bone infarction if abnormally increased or decreased uptake was present in nbs, sternum or thoracic spine. Radiographs were considered to be positive for ACS if there was pulmonary infiltrate or pleural effusion in the absence of laboratory or clinical evidence of bacterial pneumonia. ACS by chest x-ray was present in 22 episodes, 21 of which showed evidence of infarction of the bony thorax on bone scan. Thoracic bone infarction occurred in the absence of chest x-ray changes in only 11 episodes. This association between bone infarction and radiographic ACS was statistically significant (p < 0.001, Fisher's exact test). A strong association exists between ACS and infarction of the bony thorax. It is possible that bone infarction leads to pain, hypoventilation and the clinical picture of ACS.

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