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The Journal of Nuclear Medicine Vol. 34 No. 4 567-575
© 1993 by Society of Nuclear Medicine
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FDG-PET in Differentiating Lymphoma from Nonmalignant Central Nervous System Lesions in Patients with AIDS

John M. Hoffman, Hetty A. Waskin, Tobias Schifter, Michael W. Hanson, Linda Gray, Steven Rosenfeld and R. Edward Coleman

Sections of Nuclear Medicine and Neuroradiology, Department of Radiology and Divisions of Neurology and Infectious Disease, Department of Medicine, Duke University Medical Center, Durham, North Carolina

Correspondence: For correspondence or reprints contact: John M. Hoffman, MD, Section of Nuclear Medicine, Box 3949, Department of Radiology, Duke University Medical Center, Durham, NC 27710.

ABSTRACT

Structural imaging studies such a s CT or MRI are not able to accurately differentiate infectious from malignant cerebral lesions in patients with AIDS. We studied 11 individuals with AIDS and central nervous system (CNS) lesions with 18F-fluoro-2-deoxyglucose (FDG) and positron emission tomography (PET). FDG-PET was able to accurately differentiate between a malignant (lymphoma) and nonmalignant etiology for the CNS lesions. Both qualitative visual inspection of the images as well as semiquantitative analysis using count ratios was performed and revealed similar results. FDG-PET may be useful in the management of AIDS patients with CNS lesions since high FDG uptake most likely represents a malignant process which should be biopsied for confirmation rather than treated presumptively as infectious.




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Copyright © 1993 by the Society of Nuclear Medicine.