HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Williams, K. A. Articles by Foisy, M. F. Search for Related Content PubMed PubMed Citation Articles by Williams, K. A. Articles by Foisy, M. F.

First-Pass Radionuclide Angiographic Studies of Left Ventricular Function with Technetium 99m-Teboroxime, Technetium-99m-Sestamibi and Technetium-99m-DTPA

Departments of Medicine (Cardiology) and Radiology (Nuclear Medicine), University of Chicago, Chicago, Illinois

Correspondence: For correspondence or reprints contact: Kim A. Williams, MD, University of Chicago, Dir. Nuclear Cardiology, 5841 S. Maryland Ave. MC 4057, Chicago, IL 60637.

ABSTRACT

Technetium-99m-teboroxime (BATO) and ^99mTc-sestamibi (MIBI) may provide the opportunity for first-pass evaluation of left and right ventricular function at rest and exercise in conjunction with myocardial perfusion scintigraphy. This study examined the results of age- and gender-matched patients with clinically normal left ventricular function who underwent resting first-pass studies with BATO (n = 25), MIBI (n = 25) and DTPA (n = 25). There were no significant differences between the observed first-pass tracer kinetics or clinical results of MIBI and DTPA. However, there was significantly greater first-pass pulmonary uptake of BATO compared with either MIBI or DTPA. This resulted in five clinically important differences in the BATO FPRNA images: (1) greater background during the levophase of the tracer transit, (2) prolongation of the measured mean pulmonary transit time, (3) lower raw and final ejection fractions, (4) obscured left ventricular border definition resulting in larger geometrically derived left ventricular volumes and (5) poorer image detail and quality which compromised functional image and regional wall motion interpretation. This study suggests that further refinement of the first-pass methodology, particularly with regard to methods of background subtraction, is needed to obtain quality FPRNA results with BATO. However, for the purposes of left ventricular function analysis with FPRNA, MIBI and DTPA are interchangeable.