| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Division of Nuclear Medicine and Department of Internal Medicine, The University of Michigan Hospitals, Ann Arbor, Michigan
Correspondence: For correspondence and reprints contact: Markus Schwaiger, MD, Division of Nuclear Medicine, Department of Internal Medicine, University of Michigan Hospitals, 1500 E. Medical Center Drive, B1G412, Ann Arbor, MI 48109-0028.
ABSTRACT
In combination with PET, the tracer 13N-ammonia can be employed for the noninvasive quantification of myocardial perfusion at rest and after pharmacological stress. The purpose of this study was to develop an analysis method for the quantification of regional myocardial blood flow in the clinical setting. The algorithm includes correction for patient motion, an automated definition of multiple regions and display of absolute flows in polar map format. The effects of partial volume and blood to tissue cross-contamination were accounted for by optimizing the radial position of regions to meet fundamental assumptions of the kinetic model. In order to correct for motion artifacts, the myocardial displacement was manually determined based on edge-enhanced images. The obtained results exhibit the capability of the presented algorithm to noninvasively assess regional myocardial perfusion in the clinical environment.
This article has been cited by other articles:
|
|
 |
|
  S. Graf, A. Khorsand, M. Gwechenberger, C. Novotny, K. Kletter, H. Sochor, C. Pirich, G. Maurer, G. Porenta, and M. Zehetgruber Typical Chest Pain and Normal Coronary Angiogram: Cardiac Risk Factor Analysis Versus PET for Detection of Microvascular Disease J. Nucl. Med., February 1, 2007; 48(2): 175 - 181. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Herreros, F. Prosper, A. Perez, J. J Gavira, M. J. Garcia-Velloso, J. Barba, P. L Sanchez, C. Canizo, G. Rabago, J. M Marti-Climent, et al. Autologous intramyocardial injection of cultured skeletal muscle-derived stem cells in patients with non-acute myocardial infarction Eur. Heart J., November 2, 2003; 24(22): 2012 - 2020. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Kosa, R. Blasini, J. Schneider-Eicke, T. Dickfeld, F. J. Neumann, S. Ziegler, I. Matsunari, J. Neverve, A. Schomig, and M. Schwaiger Early recovery of coronary flow reserve after stent implantation as assessed by positron emission tomography J. Am. Coll. Cardiol., October 1, 1999; 34(4): 1036 - 1041. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Guethlin, A. M. Kasel, K. Coppenrath, S. Ziegler, W. Delius, and M. Schwaiger Delayed Response of Myocardial Flow Reserve to Lipid-Lowering Therapy With Fluvastatin Circulation, February 2, 1999; 99(4): 475 - 481. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Duvernoy, C. Meyer, V. Seifert-Klauss, F. Dayanikli, I. Matsunari, J. Rattenhuber, C. Hoss, H. Graeff, and M. Schwaiger Gender differences in myocardial blood flow dynamics: Lipid profile and hemodynamic effects J. Am. Coll. Cardiol., February 1, 1999; 33(2): 463 - 470. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. M. Bengel, M. Hauser, C. S. Duvernoy, A. Kuehn, S. I. Ziegler, J. C. Stollfuss, M. Beckmann, U. Sauer, O. Muzik, M. Schwaiger, et al. Myocardial blood flow and coronary flow reserve late after anatomical correction of transposition of the great arteries J. Am. Coll. Cardiol., December 1, 1998; 32(7): 1955 - 1961. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Donnelly, D. M. Raffel, B. L. Shulkin, J. R. Corbett, E. L. Bove, R. S. Mosca, and T. J. Kulik Resting coronary flow and coronary flow reserve in human infants after repair or palliation of congenital heart defects as measured by positron emission tomography J. Thorac. Cardiovasc. Surg., January 1, 1998; 115(1): 103 - 110. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. G. Camici, W. Wijns, M. Borgers, R. De Silva, R. Ferrari, J. Knuuti, A. A. Lammertsma, A. J. Liedtke, G. Paternostro, and S. F. Vatner Pathophysiological Mechanisms of Chronic Reversible Left Ventricular Dysfunction due to Coronary Artery Disease (Hibernating Myocardium) Circulation, November 4, 1997; 96(9): 3205 - 3214. [Full Text]
|
|
|
|
|
|
S. H. Rahimtoola Hibernating Myocardium Has Reduced Blood Flow at Rest That Increases With Low-Dose Dobutamine Circulation, December 15, 1996; 94(12): 3055 - 3061. [Full Text]
|
|
|
|
|
|
J. vom Dahl, O. Muzik, E. R. Wolfe Jr, C. Allman, G. Hutchins, and M. Schwaiger Myocardial Rubidium-82 Tissue Kinetics Assessed by Dynamic Positron Emission Tomography as a Marker of Myocardial Cell Membrane Integrity and Viability Circulation, January 15, 1996; 93(2): 238 - 245. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| JOURNAL OF NUCLEAR MEDICINE TECHNOLOGY | THE JOURNAL OF NUCLEAR MEDICINE |
