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Fluorine-18-Fluorodeoxyglucose Positron Emission Tomography in Technetium-99m-Hydroxymethylenediphosphate Negative Bone Tumors

Department of Radiology, Faculty of Medicine, Kyushu University, Higashi-ku, Fukuoka, Japan

Correspondence: For correspondence or reprints contact Masayuki Sasaki, MD, Department of Radiology, Faculty of Medicine. Kyushu University, 3-1-1 Maidashi, Higashiku, Fukuoka 812, Japan.

ABSTRACT

We have encountered two cases of bone tumors with high ¹⁸F-fluorodeoxyglucose (FDG) uptake and negative ^99mTc-HMDP bone scintigraphy, including a patient with myeloma and a patient with a metastatic bone tumor from esophageal cancer. Bone scintigraphy with a ^99mTc-phosphate complex reflects osteoblastic activity in the bone tissue surrounding the tumor, whereas the accumulation of FDG is associated with the metabolic activity of the tumor itself. An FDG-PET study can therefore be used as a complementary study for the detection and follow-up of bone tumors when a ^99mTc-phosphate bone scintigram is negative.

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