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Inhomogeneity of Gated and Ungated SPECT Technetium-99m-Sestamibi Bull's-Eyes in Normal Dogs: Comparison with Thallium-201

Carlyle Fraser Heart Center, Crawford Long Hospital of Emory University, Departments of Medicine (Cardiology), Radiology and Physiology, Emory University School of Medicine, Atlanta, Georgia

Correspondence: For correspondence or reprints contact: Robert L. Eisner, PhD, Carlyle Fraser Heart Center, Crawford Long Hospital of Emory University, Department of Nuclear Cardiology, 550 Peachtree St., Atlanta, GA 30365.

ABSTRACT

By computer simulation, we have previously hypothesized, independent of the isotope imaged, that differences in view-to-view resolution and attenuation patterns predictably cause count density distortions in SPECT images. We tested the simulation predictions for both ECG-gated and ungated SPECT ^99mTc-sestamibi and SPECT ²⁰¹Tl myocardial perfusion images in normal dogs. In agreement with the predictions of the computer model, distortions in SPECT ^99mTc-sestamibi myocardial perfusion images are virtually equivalent to SPECT ²⁰¹Tl, dependent on the exact SPECT acquisition orbit and markedly different for a posterior 180° acquisition arc compared to an anterior 180° acquisition arc. Furthermore, ungated and gated SPECT ^99mTc-sestamibi images show similar count inhomogeneities. These results suggest that little is to be gained from a 360° acquisition with SPECT ^99mTc-sestamibi, and that image distortions from gated or ungated SPECT ^99mTc images with 180° orbits will be similar to those in SPECT ²⁰¹Tl images.

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