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Formulation of Technetium-99m-Aerosol Colloid with Improved Delivery Efficiency for Lung Ventilation Imaging

Department of Nuclear Medicine, Ontario Cancer Institute/Princess Margaret Hospital and Faculties of Pharmacy and Medicine, University of Toronto, Toronto, Canada

Correspondence: For correspondence or reprints contact: J.R. Ballinger, PhD, Nuclear Medicine, Princess Margaret Hospital, 500 Sherbourne Street, Toronto, Ontario, Canada M4X 1K9.

ABSTRACT

Static imaging of lung ventilation in multiple views or with SPECT requires a ^99mTc aerosol which does not wash out during imaging. Commercially available ^99mTc colloids have suitable physical properties but are inefficiently delivered from jet nebulizers. An in vitro system was used to compare the delivery of various ^99mTc radiopharmaceuticals from nebulizer solutions. Delivery of noncolloidal agents (pertechnetate, pentetate, imidodiphosphate, albumin) was much greater than that of colloids. However, addition of phosphate buffer to an in-house ^99mTc-tin colloid produced an agent that was delivered as efficiently as the noncolloidal tracers and which shows promise for clinical use.