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Iodine- 131-Metaiodobenzylguanidine Scintigraphy in Preoperative and Postoperative Evaluation of Paragangliomas: Comparison with CT and MRI

Nuclear Medicine and Diagnostic Radiology Departments, Warren G. Magnuson Clinical Center
Surgery Branch, National Cancer Institute
Hypertension-Endocrine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland

Correspondence: For Correspondence or reprints contact: James C. Reynolds, MD, National Institutes of Health, Building 10, Room 1C-401, 9000 Rockvllle Pike, Bethesda, MD, 20892.

ABSTRACT

Iodine-131-metaiodobenzylguanidine (MIBG) scintigraphy, transmission computed tomography and magnetic resonance imaging were used to evaluate 36 patients with clinically suspected functioning paragangliomas. The patients were divided into two groups. In Group 1 (n = 21), studied before surgery, patients mainly had benign adrenal disease. In Group 2 (n = 15), studied after surgery, patients frequently had malignant or extra-adrenal tumors. In Group 1, transmission computed tomography and magnetic resonance imaging were more sensitive (100% for both)than MIBG scintigraphy(82%), which, however, was the most specific (100%). In Group 2, MIBG scintigraphy and magnetic resonance imaging were more sensitive (83% for both) than transmission computed tomography (75%), but MIBG was again the most specific (100%). Thus, all three were complementary modalities for localizing paragangliomas both preoperatively and postoperatively. MIBG imaging is indicated for both groups but it is especially recommended for postsurgical patients with recurrence because the disease is often malignant or extra-adrenal.

FOOTNOTES

^* Current Address: Cattedra di Medicina Nucleare, Istituto di Scienze Radiologiche, II Facolta Di Medicine e Chirugia, Universitá degli Stud Di Napoli Federico II, via S. Pansini n. 5, 80131, Napoli, Italy.

Notes: The opinions or assertions in this article are the private views of the authors and are not to be construed as official or reflecting the views of the U.S. government, nor does mention of trade names or commercial products imply endorsement by the U.S. government.

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