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Cardiac Phantom Evaluation of Simultaneously Acquired Dual-Isotope Rest Thallium-201/Stress Technetium-99m SPECT Images

Section of Nuclear Medicine, Department of Radiology, Duke University Medical Center, Durham, North Carolina

Correspondence: For correspondence or reprints contact: Val J. Lowe, MD, Section of Nuclear Medicine, Box 3949, Department of Radiology, Duke University Medical Center, Durham, NC 27710.

ABSTRACT

Simultaneously acquired dual-isotope ²⁰¹Tl/^99mTc SPECT studies were performed using cardiac and thoracic phantoms to evaluate the dual-isotope myocardial perfusion technique. Cardiac phantom images representing infarction, viable myocardium and various levels of ischemia were analyzed. Studies with and without attenuating media were performed, and myocardium-to-defect count ratios and defect sizes from dual-isotope SPECT images were compared to myocardium-to-defect count ratios and defect sizes from single-isotope (²⁰¹Tl and ^99mTc) SPECT images. Dual-isotope studies also were interpreted qualitatively. Studies with background activity simulating clinical conditions were performed and interpreted qualitatively. Myocardium-to-defect count ratios from both ^99mTc and ²⁰¹Tl were similar in single-isotope and dual-isotope SPECT images. Thallium-201 and ^99mTc defect sizes were decreased slightly (mean ± s.d., 1.0 ± 1.7 cc for ²⁰¹Tl and 0.7 ± 1.0 cc for ^99mTc) on dual studies when compared to single studies but were not statistically significant. Dual-isotope image simulations of normal, ischemic and infarcted and viable myocardium were correctly identified by experienced clinicians in 95% of the cases (21/22). Simultaneous dual-isotope ²⁰¹Tl/^99mTc SPECT imaging of cardiac phantoms produced images that had similar myocardium-to-defect count ratios to those produced using single-isotope techniques and were correctly evaluated on qualitative analysis. Changes in defect size related to dual-isotope imaging were minimal and not qualitatively important.

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				A. A. Elkamhawy and H. Chandna Minimum Detectable Defect Thickness in SPECT Myocardial Perfusion Test: Phantom Study with 99mTc and 201Tl J. Nucl. Med. Technol., December 1, 2001; 29(4): 183 - 188. [Abstract] [Full Text] [PDF]