HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Merlet, P. Articles by Randé, J. L. D. Search for Related Content PubMed PubMed Citation Articles by Merlet, P. Articles by Randé, J. L. D.

Assessment of Coronary Reserve in Man: Comparison Between Positron Emission Tomography with Oxygen-15-Labeled Water and Intracoronary Doppler Technique

Service Hospitalier Frédéric Joliot, CEA, Orsay
Service de Cardiologie, Centre Hospitalo-Universitaire Henri Mondor and INSERM U 2, Créteil, France

Correspondence: For correspondence or reprints contact: Pascal Merlet, Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, 4 place du Maréchal Leclerc, 91401 Orsay, France.

ABSTRACT

This study compared positron emission tomography (PET) using oxygen-15-labeled water for measurement of coronary reserve with intracoronary Doppler in patients with left anterior descending artery stenosis and patients with no coronary lesion and a coronary reserve 3 as assessed by the invasive technique. To determine whether PET measurement of coronary reserve is altered by partial volume effect, patients with left ventricular dysfunction due to idiopathic cardiomyopathy were studied with both techniques. Direct ultrasonic measurement of coronary reserve was performed the day prior to the PET study: a Doppler catheter was placed in the proximal left anterior descending artery; mean velocity was recorded at baseline and after dipyridamole administration. Using a time-of-flight PET system, patients underwent: (1) an intravenous bolus of oxygen-15-labeled water at baseline and 4 to 6 min after intravenous infusion of dipyridamole using the same protocol as for Doppler study and (2) a ¹⁸F-fluorodeoxyglucose (FDG) myocardial imaging. Oxygen-15 time-activity curves were recorded in myocardial regions of interest (ROIs) drawn on a static FDG image. Using the left ventricular time-activity curve as an input function, a standard model with a single-tissue compartment was fitted to the PET data; myocardial blood flow was estimated as the blood-to-tissue transfer rate constant. Coronary reserve measured by PET was well correlated with that measured by intracoronary Doppler (r = 0.98, p < 0.001 for global population). This PET method is an accurate and reliable tool to noninvasively measure coronary reserve in patients, even in those with left ventricular dysfunction.

This article has been cited by other articles:

				P. G. Camici and F. Crea Coronary Microvascular Dysfunction N. Engl. J. Med., February 22, 2007; 356(8): 830 - 840. [Full Text] [PDF]

				T. O. Kiviniemi, A. Snapir, M. Saraste, J. O. Toikka, O. T. Raitakari, M. Ahotupa, J. J. Hartiala, M. Scheinin, and J. W. Koskenvuo Determinants of coronary flow velocity reserve in healthy young men Am J Physiol Heart Circ Physiol, August 1, 2006; 291(2): H564 - H569. [Abstract] [Full Text] [PDF]

				P. A. Kaufmann and P. G. Camici Myocardial Blood Flow Measurement by PET: Technical Aspects and Clinical Applications J. Nucl. Med., January 1, 2005; 46(1): 75 - 88. [Full Text] [PDF]

				F. Frouin, P. Merlet, Y. Bouchareb, V. Frouin, J.-L. Dubois-Rande, A. De Cesare, A. Herment, A. Syrota, and A. Todd-Pokropek Validation of Myocardial Perfusion Reserve Measurements Using Regularized Factor Images of H215O Dynamic PET Scans J. Nucl. Med., December 1, 2001; 42(12): 1737 - 1746. [Abstract] [Full Text] [PDF]

				C. A. Schneider, E. Voth, D. Moka, F. M. Baer, J. Melin, A. Bol, R. Wagner, H. Schicha, E. Erdmann, and U. Sechtem Improvement of myocardial blood flow to ischemic regions by angiotensin- converting enzyme inhibition with quinaprilat IV: A study using [15O] water dobutamine stress positron emission tomography J. Am. Coll. Cardiol., October 1, 1999; 34(4): 1005 - 1011. [Abstract] [Full Text] [PDF]

				G. Junga, S. Kneifel, A.V. Smekal, H. Steinert, and U. Bauersfeld Myocardial ischaemia in children with isolated ventricular non-compaction Eur. Heart J., June 2, 1999; 20(12): 910 - 916. [Abstract] [PDF]

				P. G. Camici, W. Wijns, M. Borgers, R. De Silva, R. Ferrari, J. Knuuti, A. A. Lammertsma, A. J. Liedtke, G. Paternostro, and S. F. Vatner Pathophysiological Mechanisms of Chronic Reversible Left Ventricular Dysfunction due to Coronary Artery Disease (Hibernating Myocardium) Circulation, November 4, 1997; 96(9): 3205 - 3214. [Full Text]

				D. D. Miller, T. J. Donohue, T. L. Wolford, M. J. Kern, S. R. Bergmann, C. M. Mechem, and J. J. Hartman Assessment of Blood Flow Distal to Coronary Artery Stenoses: Correlations Between Myocardial Positron Emission Tomography and Poststenotic Intracoronary Doppler Flow Reserve Circulation, November 15, 1996; 94(10): 2447 - 2454. [Abstract] [Full Text]

				D. Annane, P. Merlet, H. Radvanyi, B. Mazoyer, B. Eymard, M. Fiorelli, C. Junien, M. Fardeau, Z. Ounnoughene, P. Gajdos, et al. Blunted Coronary Reserve in Myotonic Dystrophy An Early and Gene-Related Phenomenon: An Early and Gene-Related Phenomenon Circulation, September 1, 1996; 94(5): 973 - 977. [Abstract] [Full Text]