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Clinical Evaluation of Interictal Fluorine-18-Fluorodeoxyglucose PET in Partial Epilepsy

Department of Neurology, University of Michigan, Ann Arbor, Michigan
Departments of Neurology, Anatomy and Cell Biology and Radiological Sciences, UCLA, Los Angeles, California

Correspondence: For correspondence and reprints contact: Dr. Thomas R. Henry, Epilepsy Laboratory, University of Michigan Hospital 1B340/0036, 1500 E. Medical Center Dr., Ann Arbor, MI 48109.

ABSTRACT

Interictal [¹⁸F]fluorodeoxyglucose (FDG) positron emission tomography (PET) is useful in presurgical evaluation of medically refractory partial epilepsies. Limited replicability of image interpretation may restrict this application. We investigated interpretation replicability in 241 ¹⁸F-FDG studies performed with three different tomographs in partial epilepsy patients. Two investigators independently interpreted the studies with a standardized evaluation protocol and without knowledge of the subjects. Replicability of these unbiased interpretations in detection of regional hypometabolism was best for studies performed with the highest performance tomograph. Interictal ¹⁸F-FDG studies performed with this tomograph revealed regional hypometabolism in 62% of patients who had normal cerebral magnetic resonance imaging (MRI). Replicability of interpretations in detecting regional hypometabolism was adequate for clinical application of interictal ¹⁸F-FDG studies performed with any of the tomographs.

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