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Technetium-99m-Nanocolloid Scintigraphy in Orthopedic Infections: A Comparison with Indium-111-Labeled Leukocytes

Departments of Orthopedics and Diagnostic Radiology, Lund University Hospital, Lund, Sweden

Correspondence: For correspondence contact: Urban Rydholm. MD, Dept. of Orthopedics, University Hospital, S-22185 Lund, Sweden.

ABSTRACT

Twenty-three patients with clinically suspected acute or chronic osteomyelitis and 21 patients with suspected joint prosthetic infection underwent scintigraphy using both ^99mTc-nanocolloid and ¹¹¹In-labeled leukocytes. The scintigrams of the two tracers were blindly interpreted by three independent observers. Their evaluations showed high correspondence. Patients were classified as having no infection, probable infection or proven infection according to specific criteria which included results of bacteriological cultures and histopathological examinations. For proven and probable infection taken together, the sensitivity with ^99mTc-nanocolloid was 94%, the specificity 84% and the accuracy 87%, compared with 75%, 90% and 85% with ¹¹¹In-labeled leukocytes. We conclude that ^99mTc-nanocolloid scintigraphy is at least equivalent with ¹¹¹In-leucocyte scintigraphy, and its additional advantages are shorter examination time, less complexity and better radiation dosimetry.

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