HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bockisch, A. Articles by Biersack, H. J. Search for Related Content PubMed PubMed Citation Articles by Bockisch, A. Articles by Biersack, H. J.

Optimized Dose Planning of Radioiodine Therapy of Benign Thyroidal Diseases

Klinik für Nuklearmdizin Universität Bonn, Bonn, Germany

ABSTRACT

Thyroid uptake measurements were performed on 246 patients, who underwent radioiodine therapy for benign disease up to 192 hr after oral application of either the test activity (7 MBq) or the therapeutic activity (150–1100 MBq). Using the complete set of uptake values, the cumulated activity in the thyroid was calculated and the dose-to-activity ratio (D/A) deduced. An empiric factor was derived, which allows prediction of the D/A with high precision, using only the late uptake measurement at 96 hr or 192 hr. The correlation between the value calculated from the complete set of uptake values and that of only one at 96 hr or 192 hr was R = 0.99 and 0.97, respectively. The activity required for intended dose can thus reliably be determined by a single, late uptake measurement. In a second analysis, the correlation between the D/A of the test and the therapeutic activity was established. There were two essential findings: For those patients who were without or under stable thyroid-specific medication there was a strong correlation between the two D/A values. The therapeutic value was on the average approximately 15% lower than the test ratio, which is assumed to be due to an enhanced iodine turnover under therapeutic conditions. In patients whose medication changed dose to the test study or therapy, the measured test and therapeutic D/A were strongly noncorrelated.

FOOTNOTES

^* Present Address: Klinik mit Poliklinik für Nuklearmedizin, Johannes Gutenberg-Universität, Langenecjstraße 1, D-6500 Mainz Germany.

This article has been cited by other articles:

				W. D. Leslie, L. Ward, E. A. Salamon, S. Ludwig, R. C. Rowe, and E. A. Cowden A Randomized Comparison of Radioiodine Doses in Graves' Hyperthyroidism J. Clin. Endocrinol. Metab., March 1, 2003; 88(3): 978 - 983. [Abstract] [Full Text] [PDF]