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Quick Diagnosis of Hyperthyroidism with Semiquantitative 30-Minute Technetium-99m-Methoxy-Isobutyl-Isonitrile Thyroid Uptake

Department of Nuclear Medicine, Taichung Veterans General Hospital , Taichung, Taiwan, Republic of China

Correspondence: For reprints or correspondence contact: Chia-Hung Kao, MD, Department of Nuclear Medicine, Taichung Veterans General Hospital, 160 Taichung Harbor Road, Section 3, Taichung 40705, Taiwan, Republic of China.

ABSTRACT

Ten normal volunteers and 14 patients with hyperthyroidism had pinhole thyroid imaging 30 min after an intravenous injection of 10 mCi ^99mTc-MIBI. Technetium-99m-MIBI thyroid uptake was calculated by the formula: [total counts with a region of interest (ROI) over the whole thyroid gland] ÷ [(mean counts of every pixel in the neck soft tissue) x (total number of pixels in ROI over the whole thyroid gland)]. The results showed that the 30 min ^99mTc-MIBI thyroid uptake ratios had positive relationships with the 24 hr ¹³¹I-thyroid uptake (r = 0.79), and that the patients with hyperthyroidism had significantly higher 30 min ^99mTc-MIBI thyroid uptake than the normal volunteers (5.31 ± 0.78 s.e.m. versus 2.35 ± 0.14 s.e.m., p < 0.005 using the Mann-Whitney U-test). Technetium-99m-MIBI thyroid uptake may be useful for the rapid diagnosis of hyperthyroidism.