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Myocardial Uptake of Metaiodobenzylguanidine in Patients with Left Ventricular Hypertrophy Secondary to Valvular Aortic Stenosis

Laboratoire d'Etudes des Radiopharmaceutiques URA CNRS 1287, Faculté de Médecine Grenoble, Clinique Cardiologique, Centre Hospitalier Universitaire, Grenoble, France

Correspondence: For correspondence or reprints contact Daniel Fagret, MD, L.E.R., Dpt. de Biophysique, Faculté de Médecine, Domaine de la Merci, 38700 La Tronche, France.

ABSTRACT

The time course of myocardial uptake of metaiodobenzylguanidine ([¹²³I]MIBG) was studied in 26 patients: seven control subjects (Group 1) and 13 patients with left ventricular hypertrophy secondary to valvular aortic stenosis. Seven of these had received no treatment (Group 2) and six were receiving amiodarone or digoxin (Group3); six heart transplant recipients were investigated for extra neuronal myocardial uptake of [¹²³I]MIBG (Group 4). The index of myocardial [¹²³I]MIBG uptake was lower in Groups 2 and 3 than in Group 1 (Group 2: 1.42 ± 0.07, p < 0.001; Group 3: amiodarone, 1.30 ± 0.10, p < 0.05; digoxin, 1.22 ± 0.06, p < 0.01; Group I: 1.83 ± 0.18) and lower in Group 3 than in Group 2. Patients of Group 4 showed a much lower mean index of myocardial [¹²³I]MIBG uptake than the control group (1.07 ± 0.08, p < 0.001). In conclusion:

1. Patients with left ventricular hypertrophy secondary to valvular aortic stenosis were found to have lower myocardial [¹²³I]MIBG activity and rapid washout than the control subjects.
   
2. Amiodarone and digoxin partially inhibited myocardial [¹²³I]MIBG uptake.
   
3. Extra neuronal myocardial uptake of [¹²³I]MIBG in humans only accounts for 13% of the total cardiac activity.
   

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