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Uptake and Biodistribution of Technetium-99m-MD³²P During Rat Tibial Bone Repair

Departments of Periodontics, Pharmacology, Oral Pathology and Orthopedic Surgery, The Hebrew University-Hadassah Faculties of Dental Medicine and Medicine, Jerusalem, Israel

Correspondence: For correspondence and reprints contact: Dr. Zvi Schwartz, Department of Periodontics, School of Dental Medicine, P.O. Box 1172, Jerusalem 91010, Israel.

ABSTRACT

The present study was carried out in order to test the hypothesis that intravenously injected Tc-MDP separates into its technetium and methylene diphosphonate components in the bone, and that the technetium is preferentially taken-up by the newly-formed osteoid, while the methylene diphosphonate is taken up by the forming mineral. Uptake of Tc-MDP was studied in a rat model of primary bone formation following tibial bone marrow ablation. Each of five radiopharmaceuticals (^99mTco₄, ^99mTc-MDP, Tc-MD³²P, ^99mTc-MD³²P or MD³²P) was injected and their uptake was followed in the whole bone as well as in the organic and inorganic phases of the bone. Irrespective of the radionuclides injected, ^99mTc was always taken-up preferentially by the organic phase, while the ³²P was preferentially taken-up by the inorganic phase. When ^99mTcO₄ was injected, it was not taken up by the bone at all. These results indicate that the increased incorporation of ^99mTc, when administered as ^99mTc-MDP during bone healing, reflects an enhancement in the formation of the organic matrix and not of the calcification process. The study also suggests that the ^99mTc-MDP dissociates into its technetium and methylene diphosphonate moieties, which are then adsorbed onto the organic and inorganic phases respectively.

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