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The Technetium-99m-DTPA Renal Uptake-Plasma Volume Product: A Quantitative Estimation of Glomerular Filtration Rate

Division of Imaging Science, Department of Diagnostic Radiology, Yale University, New Haven, Connecticut
Department of Diagnostic Radiology, Saint Raphael's Hospital, New Haven, Connecticut

Correspondence: For reprints contact: Dr. I. George Zubal, Division of Imaging Science, Department of Diagnostic Radiology, Yale University, 333 Cedar St., New Haven, CT 06510.

ABSTRACT

An image-based method for estimating quantitative renal glomerular filtration rates (GFR) by calculating the product of the renal uptake rate and plasma volume is presented. By using the relationship GFR = F·PV/t, F represents renal ^99mTc-DTPA uptake after bolus injection, PV is the plasma volume and t is time. This GFR evaluation was carried out on 96 patients and compared to GFR values determined in the same patients using radiotracer blood clearance techniques relying on two venous blood samples. When estimating patient plasma volumes using patient's weight and measured hematocrit values, the image-based method for calculating GFR accurately approximates the values obtained from blood samples (linear regression slope = 1.03; y-intercept = –2.81 ml/mm). The two techniques correlate with a value of r = 0.89.