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Comprehensive Cancer Center, Departments of Radiation Oncology, Medicine, Nuclear Medicine, University of Alabama at Birmingham, and VA Medical Center, Birmingham, Alabama
University of Nebraska, Omaha, Nebraska
Lederle Laboratories, Pearl River, New York
National Cancer Institute, Bethesda, Maryland
Correspondence: For reprints contact: Ruby F. Meredith, MD, PhD, University of Alabama at Birmingham, Department of Radiation Oncology, Wallace Tumor Institute-117, Birmingham, AL 35294-3300.
ABSTRACT
Twelve patients with metastatic colon cancer were treated with 131I-chimeric B72.3 (IgG-4) at total doses of 28 or 36 mCi/m2 in two or three weekly fractions. Bone marrow suppression was the only significant side effect. The degree of bone marrow suppression adjusted for whole-body dose was modestly but statistically significantly (p = 0.04) less than that seen with identical doses given as a single infusion for the total dose of 36 mCi/m2. Nine of twelve patients developed an antibody response to ch B72.3, which altered the kinetics of radiolabeled antibody in four patients given a second course of therapy. One patient had a minor response that lasted 4 mo. Fractionation of this particular radiolabeled antibody at the dose schedule used produced a modest increase in the therapeutic window in regard to administered dose.
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