| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Morningside Park, Edinburgh, Scotland
Correspondence: For reprints contact: Dr. K.P. Ebmeier, MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Morningside Park, Edinburgh, Scotland EH10 5HF.
ABSTRACT
The study examines the sensitivity of a region of interest approach to detect functional changes in brain metabolism with SPECT and split-dose 99mTc-exametazime by replicating a simple hand movement experiment previously earned out with PET. Regional uptake of 99mTc-exametazime was determined in 12 healthy controls before and during a thumb-digit opposition task. Analysis of regional uptake was carried out blind to the hand used in the opposition task and showed a significant unilateral activation effect in a pericentral region of interest with opposite results in left- and right-handed activation. The maximum contralateral increase in tracer uptake was 16% before and 26% after correction for back diffusion. This is in good agreement with previous results employing absolute cerebral blood flow determination with PET and confirms the usefulness of 99mTc-exametazime SPECT for the examination of functional metabolic changes.
This article has been cited by other articles:
|
|
 |
|
  T. Kudo, K. Fukuchi, A. J. Annala, A. F. Chatziioannou, V. Allada, M. Dahlbom, Y.-C. Tai, M. Inubushi, S.-C. Huang, S. R. Cherry, et al. Noninvasive Measurement of Myocardial Activity Concentrations and Perfusion Defect Sizes in Rats With a New Small-Animal Positron Emission Tomograph Circulation, July 2, 2002; 106(1): 118 - 123. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. F. Kofoed, R. Bangsgaard, S. Carstensen, J. H. Svendsen, P. R. Hansen, H. Arendrup, B. Hesse, and H. Kelbaek Prolonged ischemic heart disease and coronary artery bypass -- relation to contractile reserve Eur. J. Cardiothorac. Surg., March 1, 2002; 21(3): 417 - 423. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S Shirane, M Sasaki, D Kogure, H Matsuda, and T Hashimoto Increased ictal perfusion of the thalamus in paroxysmal kinesigenic dyskinesia J. Neurol. Neurosurg. Psychiatry, September 1, 2001; 71(3): 408 - 410. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. F. Kofoed, J. Czernin, J. Johnson, J. Kobashigawa, M. E. Phelps, H. Laks, and H. R. Schelbert Effects of Cardiac Allograft Vasculopathy on Myocardial Blood Flow, Vasodilatory Capacity, and Coronary Vasomotion Circulation, February 4, 1997; 95(3): 600 - 606. [Abstract] [Full Text]
|
|
|
|
|
|
E. U. Nitzsche, Y. Choi, J. Czernin, C. K. Hoh, S.-C. Huang, and H. R. Schelbert Noninvasive Quantification of Myocardial Blood Flow in Humans : A Direct Comparison of the [13N]Ammonia and the [15O]Water Techniques Circulation, June 1, 1996; 93(11): 2000 - 2006. [Abstract] [Full Text]
|
|
|
|
|
|
J. Czernin, R. J. Barnard, K. T. Sun, J. Krivokapich, E. Nitzsche, D. Dorsey, M. E. Phelps, and H. R. Schelbert Effect of Short-term Cardiovascular Conditioning and Low-Fat Diet on Myocardial Blood Flow and Flow Reserve Circulation, July 15, 1995; 92(2): 197 - 204. [Abstract] [Full Text]
|
|
|
|
|
|
J. Czernin, K. Sun, R. Brunken, M. Bottcher, M. Phelps, and H. Schelbert Effect of Acute and Long-term Smoking on Myocardial Blood Flow and Flow Reserve Circulation, June 15, 1995; 91(12): 2891 - 2897. [Abstract] [Full Text]
|
|
|
|
|
|
M. Di Carli, J. Czernin, C. K. Hoh, V. H. Gerbaudo, R. C. Brunken, S.-C. Huang, M. E. Phelps, and H. R. Schelbert Relation Among Stenosis Severity, Myocardial Blood Flow, and Flow Reserve in Patients With Coronary Artery Disease Circulation, April 1, 1995; 91(7): 1944 - 1951. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| JOURNAL OF NUCLEAR MEDICINE TECHNOLOGY | THE JOURNAL OF NUCLEAR MEDICINE |
