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Prospective Validation of a Single Sample Technique To Determine Technetium-99m-MAG3 Clearance

Department of Radiology, Emory University Medical Center, Atlanta, Georgia
University of New Mexico, Albuquerque, New Mexico

Correspondence: For reprints contact: Andrew Taylor, Jr., MD, Emory University Hospital, Department of Radiology, 1364 Clifton Rd., N.E., Atlanta, GA 30322.

ABSTRACT

Technetium-99m-MAG3 clearance is proportional to OIH clearance and can be used directly as a measure of renal function. Multiple plasma sample, two-compartment clearance data from three studies were recently pooled to develop a single-sample regression equation for determining the clearance of ^99mTc-MAG3. To test this published equation, a prospective study was conducted in 34 patients with a wide range of renal function. Multiple plasma samples were obtained from 9 to 60 min following the bolus injection of ^99mTc-MAG3 and the clearances were calculated based on a single injection, two-compartment model. Clearances were also calculated using a single 43-min plasma sample and the published regression equation. There was an excellent correlation (r = 0.976) between the two clearances; the slope of the regression line was 1.01 with an intercept of –26.6; the standard error of the estimate was 24 ml/mm. In conclusion, the current regression equation provides a good estimate of ^99mTc-MAG3 clearance.