HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Nishimura, S. Articles by Verani, M. S. Search for Related Content PubMed PubMed Citation Articles by Nishimura, S. Articles by Verani, M. S.

Significance of Increased Lung Thallium Uptake During Adenosine Thallium-201 Scintigraphy

Section of Cardiology, Department of Internal Medicine, Baylor College of Medicine and The Methodist Hospital, Houston, Texas

Correspondence: For reprints contact: Mario S. Verani, MD, FACC, FACP, Professor of Medicine, Baylor College of Medicine, Director, Nuclear Cardiology, The Methodist Hospital, Section of Cardiology, 6535 Fannin, F-905, Houston, TX 77030.

ABSTRACT

To determine the relationship of lung ²⁰¹Tl activity during adenosine scintigraphy to the presence and extent of coronary artery disease, we investigated 132 subjects comprising 4 groups: 36 normal volunteers, 19 patients with angiographically normal coronaries, 29 patients with single-vessel (>50% luminal stenosis) and 48 patients with multivessel coronary artery disease. Lung activity was quantified relative to maximal myocardial activity in both an early anterior planar image (pretomography) and the unprocessed tomographic image in the anterior projection. A good correlation was found for the lung-to-heart ratio assessed by planar and tomographic imaging (r = 0.83, p < 0.0001), but the ratio was higher with planar imaging. The lung-to-heart ratio in the planar images was significantly higher in patients with multivessel disease compared to those with single-vessel disease (p < 0.05) or volunteers and subjects with normal coronary arteries combined (p < 0.001). A lung-to-heart ratio of >0.45 in the planar images (upper 95% confidence limit for the normal subjects) was found in 6 (21%) single-vessel disease and 17 (35%) multivessel disease patients. Patients with elevated lung thallium activity during adenosine infusion had more hypoperfused myocardial segments (p = 0.007), more segments with redistribution (p= 0.04) and larger initial perfusion defect size (p = 0.04) than those with normal lung activity. Thus, evaluation of lung activity during adenosine thallium scintigraphy provides supplementary information regarding the severity of coronary artery disease and extent of myocardial hypoperfusion.

This article has been cited by other articles:

				D. Patel, V. J.B. Robinson, R. B. Arteaga, and J. W. Thornton Diastolic Filling Parameters Derived from Myocardial Perfusion Imaging Can Predict Left Ventricular End-Diastolic Pressure at Subsequent Cardiac Catheterization J. Nucl. Med., May 1, 2008; 49(5): 746 - 751. [Abstract] [Full Text] [PDF]

				R. J. Gibbons, K. Chatterjee, J. Daley, J. S. Douglas, S. D. Fihn, J. M. Gardin, M. A. Grunwald, D. Levy, B. W. Lytle, R. A. O'Rourke, et al. ACC/AHA/ACP-ASIM guidelines for the management of patients with chronic stable angina: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Patients With Chronic Stable Angina) J. Am. Coll. Cardiol., June 1, 1999; 33(7): 2092 - 2197. [Full Text] [PDF]

				B. L. Zaret and F. J. Wackers Nuclear Cardiology- First of Two Parts N. Engl. J. Med., September 9, 1993; 329(11): 775 - 783. [Full Text]