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Gallium Imaging in Metastatic and Recurrent Soft-Tissue Sarcoma

Division of Nuclear Medicine, Joint Program in Nuclear Medicine, Department of Radiology, Department of Medicine, and Division of Biostatistics and Epidemiology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts

Correspondence: Reprints are not available from the authors.

ABSTRACT

Fifty-six patients with metastatic or recurrent soft-tissue sarcoma were evaluated by ⁶⁷Ga-citrate imaging. Prior to entry on the therapy protocol, 52/56 (93%) patients had true positive ⁶⁷Ga studies. Two of four patients with liposarcoma, one of twelve with leiomyosarcoma and one with an epitheliold sarcoma had false-negative studies; 89/105 disease sites (85%) were ⁶⁷Ga positive, including 100% of pleural lesions, 94% in bone, 88% in the abdomen, 85% in soft tissue, 78% in lung parenchyma and 56% of liver metastases. There was significant association between ⁶⁷Ga avidity and tumor grade with the exception of mesothelioma. No relationship was seen between ⁶⁷Ga avidity and tumor cell type, disease site or lesion size. Following therapy, ⁶⁷Ga correctly identified 11/12 sites of active disease in 8/9 patients. Mean pre- and post-therapy ⁶⁷Ga avidity scores did not differ significantly. Gallium-67 appears to have an important role in the evaluation of patients presenting with either primary or metastatic soft-tissue sarcoma.

FOOTNOTES

^* Current address: Royal Newcastle Hospital, Newcastle, NSW 23400 Australia.