| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Departments of Internal Medicine, Division of Nuclear Medicine, Radiology and Surgery, University of Michigan Medical Center, Ann Arbor, Michigan
Correspondence: For reprints contact: Barry L. Shulkin, MD, University of Michigan Medical Center, Pediatric Nuclear Medicine, MCHC F3341, Ann Arbor, MI 48109-0229.
ABSTRACT
Pheochromocytomas are potentially curable causes of hypertension. These tumors are currently located by functional imaging with meta-iodobenzylguanidine (MIBG), usually labeled with 131I, or anatomic imaging (computed tomography, magnetic resonance). Hydroxyephedrine (HED) is a newly developed radiotracer that concentrates in adrenergic nerve terminals. When HED is labeled with 11C, its distribution can be mapped in vivo using PET. The purposes of this investigation were to characterize the uptake of 11C-HED in pheochromocytoma and to determine the feasibility and advantages of utilizing this compound as a tumor imaging agent. Ten patients with known or suspected pheochromocytoma were studied. Each patient underwent PET scanning with 11C-HED and conventional scintigraphy with MIBG. Pheochromocytomas were localized by PET scanning in 9 of the 10 patients. Image quality was excellent and superior to that obtained from planar and tomographic MIBG studies. The uptake of 11C-HED into pheochromocytomas was rapid; tumors were evident within 5 min following intravenous injection. All lesions within the field of view that were identified by MIBG scintigraphy were readily apparent. PET scanning with 11C-HED localizes pheochromocytoma using a specifically designed radiotracer and advanced imaging technology. The method has promise for locating the more elusive tumors.
This article has been cited by other articles:
|
|
 |
|
  I. Ilias, C. C. Chen, J. A. Carrasquillo, M. Whatley, A. Ling, I. Lazurova, K. T. Adams, S. Perera, and K. Pacak Comparison of 6-18F-Fluorodopamine PET with 123I-Metaiodobenzylguanidine and 111In-Pentetreotide Scintigraphy in Localization of Nonmetastatic and Metastatic Pheochromocytoma J. Nucl. Med., October 1, 2008; 49(10): 1613 - 1619. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. T. Adler, G. Y. Meyer-Rochow, H. Chen, D. E. Benn, B. G. Robinson, R. S. Sippel, and S. B. Sidhu Pheochromocytoma: Current Approaches and Future Directions Oncologist, July 1, 2008; 13(7): 779 - 793. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Karagiannis, D. P Mikhailidis, V. G Athyros, and F. Harsoulis Pheochromocytoma: an update on genetics and management Endocr. Relat. Cancer, December 1, 2007; 14(4): 935 - 956. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. T. Thackeray, R. S. Beanlands, and J. N. DaSilva Presence of Specific 11C-meta-Hydroxyephedrine Retention in Heart, Lung, Pancreas, and Brown Adipose Tissue J. Nucl. Med., October 1, 2007; 48(10): 1733 - 1740. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Chrisoulidou, G. Kaltsas, I. Ilias, and A. B Grossman The diagnosis and management of malignant phaeochromocytoma and paraganglioma Endocr. Relat. Cancer, September 1, 2007; 14(3): 569 - 585. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Franzius, K. Hermann, M. Weckesser, K. Kopka, K. U. Juergens, J. Vormoor, and O. Schober Whole-Body PET/CT with 11C-Meta-Hydroxyephedrine in Tumors of the Sympathetic Nervous System: Feasibility Study and Comparison with 123I-MIBG SPECT/CT J. Nucl. Med., October 1, 2006; 47(10): 1635 - 1642. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. N. Mann, J. M. Link, P. Pham, C. A. Pickett, D. R. Byrd, P. E. Kinahan, K. A. Krohn, and D. A. Mankoff [11C]Metahydroxyephedrine and [18F]Fluorodeoxyglucose Positron Emission Tomography Improve Clinical Decision Making in Suspected Pheochromocytoma Ann. Surg. Oncol., February 1, 2006; 13(2): 187 - 197. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Buursma, A. M.J. Beerens, E. F.J. de Vries, A. van Waarde, M. G. Rots, G. A.P. Hospers, W. Vaalburg, and H. J. Haisma The Human Norepinephrine Transporter in Combination with 11C-m-Hydroxyephedrine as a Reporter Gene/Reporter Probe for PET of Gene Therapy J. Nucl. Med., December 1, 2005; 46(12): 2068 - 2075. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Pacak, G. Eisenhofer, and D. S. Goldstein Functional Imaging of Endocrine Tumors: Role of Positron Emission Tomography Endocr. Rev., August 1, 2004; 25(4): 568 - 580. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S. Goldstein, G. Eisenhofer, J. A. Flynn, G. Wand, and K. Pacak Diagnosis and Localization of Pheochromocytoma Hypertension, May 1, 2004; 43(5): 907 - 910. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Ilias and K. Pacak Current Approaches and Recommended Algorithm for the Diagnostic Localization of Pheochromocytoma J. Clin. Endocrinol. Metab., February 1, 2004; 89(2): 479 - 491. [Full Text] [PDF]
|
|
|
|
 |
|
 C. Trampal, H. Engler, C. Juhlin, M. Bergstrom, and B. Langstrom Pheochromocytomas: Detection with 11C Hydroxyephedrine PET Radiology, February 1, 2004; 230(2): 423 - 428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Ilias, J. Yu, J. A. Carrasquillo, C. C. Chen, G. Eisenhofer, M. Whatley, B. McElroy, and K. Pacak Superiority of 6-[18F]-Fluorodopamine Positron Emission Tomography Versus [131I]-Metaiodobenzylguanidine Scintigraphy in the Localization of Metastatic Pheochromocytoma J. Clin. Endocrinol. Metab., September 1, 2003; 88(9): 4083 - 4087. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. L. Bravo and R. Tagle Pheochromocytoma: State-of-the-Art and Future Prospects Endocr. Rev., August 1, 2003; 24(4): 539 - 553. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Maurea, M. Klain, C. Mainolfi, M. Ziviello, and M. Salvatore The Diagnostic Role of Radionuclide Imaging in Evaluation of Patients with Nonhypersecreting Adrenal Masses J. Nucl. Med., June 1, 2001; 42(6): 884 - 892. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Dimitrakopoulou-Strauss, L. G. Strauss, and C. Burger Quantitative PET Studies in Pretreated Melanoma Patients: A Comparison of 6-[18F]Fluoro-L-Dopa with 18F-FDG and 15O-Water Using Compartment and Noncompartment Analysis J. Nucl. Med., February 1, 2001; 42(2): 248 - 256. [Abstract] [Full Text]
|
|
|
|
|
|
B. L. Shulkin, N. W. Thompson, B. Shapiro, I. R. Francis, and J. C. Sisson Pheochromocytomas: Imaging with 2-[Fluorine-18]fluoro-2-deoxy-D-glucose PET Radiology, July 1, 1999; 212(1): 35 - 41. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. Malizia, G. Forse, A. Haida, R. Gunn, J. Melichar, K. Poole, D. Bateman, D. Fahy, L. Schnorr, D. Brown, et al. A new human (psycho)pharmacology tool: the multiple organs coincidences counter (MOCC) J Psychopharmacol, January 1, 1995; 9(4): 294 - 306. [Abstract] [PDF]
|
|
|
|
|
|
S. Hoegerle, E. Nitzsche, C. Altehoefer, N. Ghanem, T. Manz, I. Brink, M. Reincke, E. Moser, and H. P. H. Neumann Pheochromocytomas: Detection with 18F DOPA Whole-Body PET3Initial Results Radiology, February 1, 2002; 222(2): 507 - 512. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| JOURNAL OF NUCLEAR MEDICINE TECHNOLOGY | THE JOURNAL OF NUCLEAR MEDICINE |
