HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Lee, H. B. Articles by Blaufox, M. D. Search for Related Content PubMed PubMed Citation Articles by Lee, H. B. Articles by Blaufox, M. D.

Renal Functional Response to Captopril During Diuretic Therapy

Department of Nuclear Medicine, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York

Correspondence: For reprints contact: M. Donald Blaufox, MD, PhD, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461.

ABSTRACT

Antihypertensive agents may modify the renal effects of angiotensin converting enzyme inhibition (ACEI). This potential interaction, which is important in the diagnosis of renovascular hypertension was studied in two rat models with and without diuretic treatment prior to ACEI. Acute intravenous administration of furosemide or hydrochlorothiazide in one-kidney, one-clamp animals (1K1C) did not change glomerular filtration rate (GFR) or effective renal plasma flow (ERPF). ACEI administration after furosemide and hydrochlorothiazide decreased GFR(p < 0.001, p < 0.01) but not ERPF. Chlorothiazide administered to 1K1C prior to ACEI, decreased GFR (p < 0.02) but not ERPF captopril administration to 1K1C which received hydrochlorothiazide intraperitoneally for 7–10 days decreased GFR (p < 0.007) and ERPF (p < 0.02), while two-kidney, one-clamp animals (2K1C) decreased GFR only in the clamped kidney (p < 0.005). ERPF in 2K1C increased only in the contralateral kidney (p < 0.01). Without diuretic 1K1C animals decreased GFR and ERPF after ACEI (p < 0.005, P < 0.001). In the clamped kidney of 2K1C rats, GFR and ERPF decreased significantly (p < 0.0005, p < 0.004) and contralateral kidney ERPF increased (p < 0.001), but GFR did not. The consequences of ACEI on GFR are similar with or without diuretic. These data suggest that diuretic therapy may not significantly interfere with ACEI evaluation of renovascular hypertension.