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Carbon-11-Methionine and PET Is an Effective Method To Image Head and Neck Cancer

Departments of Oncology and Radiotherapy, Nuclear Medicine and the Turku Medical Cyclotron-PET Center Turku University Central Hospital, Turku, Finland

Correspondence: For reprints contact: Sirkku Leskinen-Kallio, MD, Department of Oncology and Radiotherapy, Turku University Central Hospital, SF-20520 Turku, Finland.

ABSTRACT

Methionine metabolism is altered in cancer, and methionine labeled with ¹¹C has been successfully used for imaging of brain, lung, and breast cancer and lymphoma. Uptake of L-[methyl-¹¹C]methionine (¹¹C-methionine) in head and neck cancer of 23 patients was studied with PET. Accumulation of ¹¹C-methionine in the tumors was assessed by two different methods: the influx constant, K_i, and the standardized uptake value (SUV). All 23 cancers accumulated ¹¹C-methionine. The mean K_i was 0.147 ± 0.070 min ^–1 and the mean SUV 8.5 ± 3.5. There was a strong correlation between the two measures of tumor uptake (r = 0.92, p < 0.0001). There was no correlation between the uptake of ¹¹C-methionine and the histological grade of cancer. Head and neck cancer can thus be effectively imaged with ¹¹C-methionine. Carbon-11-methionine PET imaging may be useful in delineating tumors for therapy planning.

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