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Biodistribution and Kinetics of Radiolabeled Proteins in Rats with Focal Infection

Departments of Nuclear Medicine and Internal Medicine, University Hospital Nijmegen, and Division of General Internal Medicine, Nijmegen, The Netherlands

Correspondence: For reprints contact: Wim J.G. Oyen, MD, Department of Nuclear Medicine, University Hospital Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.

ABSTRACT

The purpose of this study was to evaluate the role of both protein and radionuclide in the accumulation of ¹¹¹In-labeled human immunoglobulin G (IgG) in infectious foci. In rats with a calf muscle infection, biodistribution was determined 2, 6, 24, and 48 hr after injection of a radiopharmaceutical. For IgG, human serum albumin (HSA) and human immunoglobulin A (IgA), all labeled with ¹¹¹In, target-to-background (T/B) ratios were similar throughout the study. However, absolute abscess uptake of ¹¹¹In-IgA was significantly lower. For IgG labeled with ¹¹¹In, ¹²³I, or ^99mTc, similar T/B ratios were found up to 24 hr. After 48 hr, the T/B ratio of ¹¹¹In-IgG was significantly higher than the T/B ratio of ¹²³I-IgG. The absolute abscess uptake of ¹¹¹In-IgG was higher than that of ^99mTc-IgG at 24 hr and ¹²³I-IgG at 48 hr. In conclusion, the radionuclide appears to be of major importance in the accumulation of radiolabeled proteins in infectious foci. Protein mainly influences blood clearance and distribution in organs. The Fc- receptor is not crucial for accumulation in infectious foci.

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