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Myocardial Perfusion at Fatal Infarction: Location and Size of Scintigraphic Defects

Departments of Clinical Physiology/Nuclear Medicine, Internal Medicine, and Pathology, Herlev Hospital, University of Copenhagen, Denmark

Correspondence: For reprints contact: K.A.S. Herlev, 54P1, DK-2730, Dept. of Clinical Physiology/Nuclear Medicine, Herten Hospital, University of Copenhagen, Copenhagen, Denmark.

ABSTRACT

In a consecutive study of myocardial scintigraphy in acute ischemic syndrome, four patients had ^99mTc-hexamibi injected intravenously before they developed fatal cardiogenic shock. Planar scintigraphy was performed after death. Slices of the hearts after autopsy were analyzed for scintigraphic and pathoanatomic abnormalities. Location of perfusion defects in planar views of the heart was in good agreement with the scintigraphied, sliced sections. The extent of infarction judged from inspection and formasan staining was much smaller (7%–40% and 6%–43% of the total slice area) than found at scintigraphy, where 83%–92% of the myocardium showed ischemia as defined by a ^99mTc-hexamibi uptake below an arbitrary limit on half maximum uptake. Myocardial hypoperfusion might thus aggravate the functional impairment at myocardial infarction and lead to cardiogenic shock.