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Cerebral Glucose Metabolic Rates After 30 and 45 Minute Acquisitions: A Comparative Study

Laboratory of Neurosciences, National Institute on Aging and The Positron Emission Tomography Department, NIH Clinical Center, Bethesda, Maryland

Correspondence: For reprints contact: Anand Kumar, Section of Geriatric Psychiatry, University of Pennsylvania School of Medicine, 3615 Chestnut St., Philadelphia, PA 19104.

ABSTRACT

This study was undertaken to determine if measurements of absolute regional cerebral metabolic rate for glucose (rCMRglc) and variance of rCMRglc are independent of time between 30 and 45 min following injection of the radiotracer. Sixteen subjects received two sets of ¹⁸FDG PET scans commencing 30 and45 min following intravenous injection of ¹⁸FDG. No statistically significant differences were detected in either absolute rCMRglc or rCMRglc variance between the two sets of scans. These data demonstrate that for most FDG PET studies, scanning can commence 30 min after injection of the radiotracer without compromising the metabolic data.

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