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A Quantitative Autoradiographic Study of the Heterogeneous Activity Distribution of Different Indium-111-Labeled Radiopharmaceuticals in Rat Tissues

Department of Radiation Physics, University of Lund and Department of Toxicology, University of Uppsala, Sweden

Correspondence: For reprints contact: Bo-Anders Jönsson, PhD, Department of Radiation Physics, University of Lund, Lasarettet, S-221 85 Lund, Sweden.

ABSTRACT

In light of the increased interest in small scale dosimetry, this paper presents a quantitative autoradiographic method for evaluation of heterogeneous activity distribution in tissues. This was studied in rat tissues after administration of ¹¹¹In-chloride, -oxine, -tropolone, ¹¹¹In-labeled homologous blood cells and ¹¹¹In-anti-CEA-F(ab')₂, using quantitative whole body autoradiography. Quantification was performed utilizing an image analyzing system designed for whole-body autoradiographs. very heterogeneous activity distribution was found in several tissues including the liver, spleen, kidneys, bone marrow, lymphnodes and testes. Notable was the high ¹¹¹In uptake in organs characterized as rapidly proliferating, and known to have numerous transferrin receptors. In the gastrointestinal tract, all activity was associated with the intestinal walls. The heterogeneous tissue distribution shown in this investigation accentuates the necessity for performing detailed studies of the tissue distribution of radiopharmaceuticals. This is especially important for the radiation dosimetry of radionuclides emitting beta-particles or low energy electrons. We suggest whole-body autoradiography as an excellent implement to determine local activity concentrations in organs and tissues necessary for accurate absorbed dose calculations.

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