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Planar Myocardial Perfusion Imaging with Technetium-99m-Teboroxime: Comparison by Vascular Territory with Thallium-201 and Coronary Angiography

Departments of Nuclear Medicine and Medicine (Division of Cardiology) and the Myocardial Isotope Research Laboratory, University of Massachusetts Medical Center, Worcester, Massachusetts
Department of Medicine (Sections of Cardiology and Critical Care), Northwestern University Medical School, Chicago, Illinois

Correspondence: For reprints contact: Seth T. Dahlberg, Department of Nuclear Medicine, University of Massachusetts Medical Center, 55 Lake Avenue North, Worcester, MA 01655.

ABSTRACT

Myocardial perfusion agents labeled with ^99mTc offer improved physical imaging properties compared to ²⁰¹Tl. Teboroxime is a new ^99mTc-labeled compound for myocardial perfusion imaging that shows a high myocardial extraction and rapid clearance. Sixty-seven patients underwent planar teboroxime imaging with a rapid acquisition protocol. Agreement of teboroxime and ²⁰¹Tl for the presence or absence of disease occurred in 56/65 patients (86%). There was agreement (normal or abnormal) between the two agents in 156/195 vessels (80%) and 457/585 segments (78%).When abnormal segments (ischemia or infarction) were compared, teboroxime showed significantly more ischemic segments (89/135, 66%) than did ²⁰¹Tl (73/135, 54%, p < 0.05). Teboroxime offers accuracy comparable to ²⁰¹Tl for the diagnosis of coronary artery disease and may improve the detection of ischemic or viable myocardium. In addition, its rapid myocardial clearance permits stress/rest imaging in 60–90 min.

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				D. D. Miller The Growing Flood of Technetium-99m Myocardial Perfusion Agents : More Water . . . or More Mud? Circulation, January 15, 1995; 91(2): 555 - 558. [Abstract] [Full Text]