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Colon Carcinoma Immunoscintigraphy by Monoclonal Anti-CEA Antibody Labeled with Gallium-67-Aminooxyacetyldeferroxamine

Division de Médecine Nucléaire and Clinique de Chirurgie Digestive, Hôpital Cantonal Universitaire, Geneva, Switzerland
Département de Biochimie Médicale and Institut de Pathologie Clinique, Centre Médical Universitaire, Geneva, Switzerland
Institut de Biochimie, Université de Lausanne, Epalinges, Switzerland

Correspondence: For reprints contact: Jean-Etienne Ryser, MD, Division de Médecine Nucléaire, Hôpital Cantonal Universitaire de Genève, 1211 Geneva 4, Switzerland.

ABSTRACT

Previous experimental results in nude mice showing that radiolabeling the monoclonal antibody anti-CEA 35 with ⁶⁷Ga-aminooxyacetyldeferroxamine could give better tumor localization than radioiodination prompted us to initiate the present clinical study. The ⁶⁷Ga-labeled antibody anti-CEA 35 (185 MBq, 0.7–1.7 mg) was injected preoperatively into 14 patients for colorectal carcinoma imaging. The same antibody labeled with ¹²⁵I (3.7 MBq, 0.25 mg) was injected simultaneously to compare the ⁶⁷Ga and ¹²⁵I dose recoveries in surgical specimens. Twelve of 14 primary tumors gave a positive ⁶⁷Ga scintigraph. The mean %ID/g recovered in all tumors 3–9 days after injection was significantly higher for ⁶⁷Ga (0.019%) than for ¹²⁵I (0.005%) (p < 0.001, paired test). The tumor-to-normal tissue ratios were generally higher for ⁶⁷Ga, with the exception of liver. We conclude that ⁶⁷Ga-aminooxyacetyldeferroxamine improved immunoscintigraphy outside the liver, particularly in the pelvic region. We also show that deferroxamine infusion accelerates the excretion of ⁶⁷Ga in eight patients and propose that this could lead to further improvement of immunoscintigraphy.