HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Gordon, I. Articles by Evans, K. Search for Related Content PubMed PubMed Citation Articles by Gordon, I. Articles by Evans, K.

Estimation of Technetium-99m-MAG₃ Renal Clearance in Children: Two Gamma Camera Techniques Compared with Multiple Plasma Samples

Department of Radiology, Hospital for Sick Children, London, England

Correspondence: For reprints contact: Isky Gordon, Department of Radiology, Hospital for Sick Children, Great Ormond St., London, England WC1N 3JH.

ABSTRACT

Dynamic renal scintigraphy using technetium-99m mercaptoacetylglycylglycylglycine (MAG₃) has been described in adults, and clearance values have been established using multiple plasma samples. This study of renal clearance has compared two fundamentally different gamma camera techniques (both of which require a single blood sample) with the multiple blood sampling technique in children (n = 30). Results show that a 40-min dynamic ^99mTc-MAG₃ renal scintigram coupled with a single plasma sample will allow analysis of the data so that clearance values, which are similar to those from multiple plasma samples, may be calculated. The curve generated from the cardiac region of interest (ROI) provided clearances values that had a high correlation coefficient (0.939–0.951) compared to the multiple-plasma sample technique immaterial of the timing of the blood sample. The renal uptake method of clearance had a lower correlation coefficient (0.89–0.92), which varied with the timing of the blood sample compared to the multiple-plasma sampling technique. This study has demonstrated that an extended gamma camera acquisition coupled with a single-plasma sample may be used for quantitative renal function studies using ^99mTc-MAG₃.