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Comparison of Oral Iodine-131-Cellulose and Indium-111-DTPA as Tracers for Colon Transit Scintigraphy: Analysis by Colon Activity Profiles

Departments of Nuclear Medicine and Gastroenterology and the Colorectal Unit, St. George Hospital, Sydney, NSW, Australia

Correspondence: For reprints contact: R. C. Smart, PhD, Department of Nuclear Medicine, St. George Hospital, Belgrave St., Kogarah, Sydney, NSW 2217, Australia.

ABSTRACT

In 11 normal subjects and 11 patients with a clinical diagnosis of constipation, oral ¹³¹I-cellulose and ¹¹¹In-DTPA were compared simultaneously as tracers for radionuclide colon transit scintigraphy. Visual assessment of the images revealed no differences between tracers. Quantitation was performed using total and segmental percent retention and the derived value of clearance half-time. In addition, profiles of the activity distribution along the length of the colon were generated and the mean position of the activity in the colon calculated. For all indices, the results were similar in both normal subjects and constipated patients when comparing tracers, although marked differences were present between normal subjects and constipated patients for each tracer. Indium-111-DTPA was easy to administer and dosimetry was more acceptable than for ¹³¹I-cellulose, especially in constipated patients. It is concluded that ¹¹¹In-DTPA is the preferred tracer for oral colon transit scintigraphy.

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