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The Journal of Nuclear Medicine Vol. 32 No. 8 1608-1610
© 1991 by Society of Nuclear Medicine
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PET Study of Carbon-11-PK 11195 Binding to Peripheral Type Benzodiazepine Sites in Glioblastoma: A Case Report

S. Pappata , P. Cornu, Y. Samson, C. Prenant, J. Benavides, B. Scatton, C. Crouzel, J. J. Hauw and A. Syrota

INSERM U. 334 Service Hospitalier Frédéric Joliot and C. E. A., Orsay, France; Service de Neurochirurgie, Hôpital de la Salpêtrière, Paris, France; Departement de Biologie, Laboratoire d'Etudes et de Recherches Synthelabo, Bagneux, France; and Laboratoire de Neuropathologie, R. Escourolle Hôpital de la Salpêtrière, Paris, France

Correspondence: For reprints contact: S. Pappata, INSERM Unité 334. Service Hospitalier Federic Joliot, F-91406 Orsay, France.

ABSTRACT

The utility of the peripheral type benzodiazepine site ligand 11C-PK 11195, for imaging human glioma in conjunction with Positron Emission Tomography, relies on a high specific binding of the tracer to tumoral peripheral type benzodiazepines sites. In a patient with glioblastoma, we found that 11C-PK 11195 binding was two-fold higher in the tumor than in normal gray matter and that 30% of tumoral binding could be displaced by a large excess of unlabeled drug. These findings suggest that tumoral retention of the ligand is due, in part, to specific binding.




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