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Malignant Transformation of a Hürthle Cell Tumor: Case Report and Survey of the Literature

Nuclear Medicine Service, Medical Service, and Laboratory Service, VA Medical Center, Long Beach, California
Department of Radiological Sciences, and Department of Medicine, University of California, Irvine, California
Nuclear Medicine Service, Wadsworth-UCLA VA Medical Center, Los Angeles, California

Correspondence: For reprints contact: Sing-yung Wu, MD, PhD, Nuclear Medicine Service, VA Medical Center, Long Beach, CA 90822.

ABSTRACT

Hürthle cell carcinoma is a relatively uncommon type of well-differentiated thyroid carcinoma. Its diagnosis has been controversial due to the difficulty in separating Hürthle cell adenoma from Hürthle cell carcinoma, thus the term Hürthle cell tumor is often used to describe both lesions. The present case of anaplastic giant-cell carcinoma in an 81-yr-old woman arose in a Hürthle cell tumor. This case illustrates the propensity of Hürthle cell tumor to undergo "malignant transformation" and argues for a more aggressive approach to such tumors.