HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Israel, O. Articles by Kolodny, G. M. Search for Related Content PubMed PubMed Citation Articles by Israel, O. Articles by Kolodny, G. M.

In Vivo SPECT Quantitation of Bone Metabolism in Hyperparathyroidism and Thyrotoxicosis

Department of Nuclear Medicine and Division of Endocrinology, Rambam Medical Center
Department of Nuclear Medicine, Lady Davis Carmel Hospital
Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel

Correspondence: For reprints contact: Dov Front, MD, PhD, Department of Nuclear Medicine, Rambam Medical Center, Haifa 35254, Israel.

ABSTRACT

Bone metabolism was assessed in vivo and noninvasively using quantitative SPECT. The effect of endocrine abnormalities on bone metabolism was studied in 27 patients with primary hyperparathyroidism (HPT) and 12 patients with thyrotoxicosis (TTX). Quantitative bone scintigraphy (QBS) values of ^99mTc-MDP uptake were compared to normal values matched for sex and age. Bones with significantly increased QBS values indicating increased bone metabolism were identified in the two patient groups. Fifty-one percent of the bones in patients with HPT and 78% in patients with TTX showed significantly increased QBS values. Increase in bone metabolism was highestin the femoral shaft. Seven patients with HPT and five with TTX were successfully treated. Six patients with HPT and four patients with TTX showed significant decrease of bone metabolism with normal QBS values after three months. The results indicate that QBS can be used to evaluate bone metabolism and its response to treatment in individual bones in patients with endocrine abnormalities.

This article has been cited by other articles:

				G J R Cook and I Fogelman Bone single photon emission computed tomography Imaging, September 1, 2001; 13(3): 149 - 154. [Abstract] [Full Text] [PDF]