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Parametric Images of Myocardial Metabolic Rate of Glucose Generated from Dynamic Cardiac PET and 2-[¹⁸F]Fluoro-2-deoxy-d-glucose Studies

Division of Nuclear Medicine and Biophysics, Department of Radiological Sciences, Laboratory of Nuclear Medicine (DoE), and The Crump Institute, UCLA School of Medicine, Los Angeles, California

Correspondence: For reprints contact Randall A. Hawkins, MD, PhD, Division of Nuclear Medicine and Biophysics, Department of Radiological Sciences, UCLA School of Medicine, Los Angeles, CA.

ABSTRACT

We describe a method for generating parametric images of the myocardial metabolic rate of glucose (MMRGIc) with positron emission tomography (PET). The method employs serially acquired images of 2-[¹⁸F]fluoro-2-deoxy-D-glucose (FDG) uptake and a Patlak graphical analysis of the image data. The arterial input function is derived from images of the left ventricular blood pool calibrated with ¹⁸F-plasma measurements. The approach is computationally fast enough to be used in a clinical environment. The MMRGIc parametric images improve myocardial contrast relative to non-parametric images, especially in studies with poor myocardial uptake of FDG. In addition, MMRGIc parametric images consolidate the large amount of data in a dynamic PET study into a clinically usable image set.

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