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Division of Nuclear Medicine and Biophysics, Department of Radiological Sciences, UCLA School of Medicine, Los Angeles, California
Laboratory of Nuclear Medicine, Laboratory of Biomedical and Environmental Sciences, University of California, Los Angeles, California
Correspondence: For reprints contact: Sammy Y. Chan, MD, Division of Nuclear Medicine and Biophysics, UCLA School of Medicine, Los Angeles, CA 90024-1721.
ABSTRACT
The high first-pass myocardial extraction fraction of carbon-11-acetate suggests that its initial uptake depends on blood flow. Accordingly, regional uptake of 11C-acetate at 4 min was compared to regional perfusion determined with nitrogen-13-ammonia in 119 segments in 15 patients with stable coronary artery disease by two methods. A close correlation was observed between initial relative myocardial concentrations (segmental activity normalized to maximal activity) of both tracers (11C-acetate = 0.88; 13N-ammonia + 0.079; s.e.e. = 0.064, r = 0.94, p < 0.001). Furthermore, segmental net extractions (E·F), as calculated from the input function and segmental activities, of the two tracers correlated closely by E·FC–11 = 0.55E·FN–13 + 0.080 (s.e.e. = 0.045, r = 0.87, p < 0.001). These relationships indicate that initial regional myocardial uptake of 11C-acetate reflects perfusion and that 11C-acetate permits near simultaneous evaluation of regional oxidative metabolism and of regional myocardial perfusion.
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