JNM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH RSS TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

The Journal of Nuclear Medicine Vol. 32 No. 2 245-251
© 1991 by Society of Nuclear Medicine
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gropler, R. J.
Right arrow Articles by Geltman, E. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gropler, R. J.
Right arrow Articles by Geltman, E. M.

Myocardial Uptake of Carbon-11-Acetate as an Indirect Estimate of Regional Myocardial Blood Flow

Robert J. Gropler, Barry A. Siegel and Edward M. Geltman

Division of Nuclear Medicine, Edward Mallinckrodt Institute of Radiology and Cardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri

Correspondence: For reprints contact: Robert J. Gropler, MD, Division of Nuclear Medicine, Mallinckrodt Institute of Radiology, 510 S. Kingshighway Blvd., St. Louis, MO 63110.

ABSTRACT

The rate of clearance of myocardial carbon-11 (11C) activity (after the administration of 11C-acetate) has been shown to correlate closely with myocardial oxygen consumption. In the present study, we hypothesized that regional net myocardial uptake of 11C-acetate, which reflects primarily delivery and extraction of tracer, would be markedly flow-dependent and potentially useful as an indirect index of regional myocardial blood flow. In 22 patients with stable coronary artery disease, the regional distribution of early net uptake of 11C-acetate was correlated with estimates of regional myocardial blood flow assessed with oxygen-15-water. The myocardial images of 11C-acetate uptake were of high quality. The correlation between the two approaches was close (r = 0.88) and not affected by the metabolic state of the tissue. Thus, in patients with stable coronary artery disease, under resting conditions, direct estimates of myocardial oxygen consumption in relation to the level of delivery of tracer to the tissue can now be obtained by PET with use of a single radiopharmaceutical, 11C-acetate. This approach may prove particularly useful in streamlining clinical protocols designed to assess myocardial oxygen consumption.




This article has been cited by other articles:


Home page
 JNMHome page
N. Pillarsetty, B. Punzalan, and S. M. Larson
2-18F-Fluoropropionic Acid as a PET Imaging Agent for Prostate Cancer
J. Nucl. Med., October 1, 2009; 50(10): 1709 - 1714.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
P. Herrero, J. Kim, T. L. Sharp, J. A. Engelbach, J. S. Lewis, R. J. Gropler, and M. J. Welch
Assessment of Myocardial Blood Flow Using 15O-Water and 1-11C-Acetate in Rats with Small-Animal PET
J. Nucl. Med., March 1, 2006; 47(3): 477 - 485.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
K. Yoshinaga, C. Katoh, R. S.B. Beanlands, K. Noriyasu, K. Komuro, S. Yamada, Y. Kuge, K. Morita, A. Kitabatake, and N. Tamaki
Reduced Oxidative Metabolic Response in Dysfunctional Myocardium with Preserved Glucose Metabolism but with Impaired Contractile Reserve
J. Nucl. Med., November 1, 2004; 45(11): 1885 - 1891.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
F.M. Bengel, B. Permanetter, M. Ungerer, S.G. Nekolla, and M. Schwaiger
Relationship between altered sympathetic innervation, oxidative metabolism and contractile function in the cardiomyopathic human heart; a non-invasive study using positron emission tomography
Eur. Heart J., September 1, 2001; 22(17): 1594 - 1600.
[Abstract] [PDF]

Home page
 JNMHome page
J. van den Hoff, W. Burchert, A.-R. Borner, H. Fricke, G. Kuhnel, G. J. Meyer, D. Otto, E. Weckesser, H.-G. Wolpers, and W. H. Knapp
[1-11C]Acetate as a Quantitative Perfusion Tracer in Myocardial PET
J. Nucl. Med., August 1, 2001; 42(8): 1174 - 1182.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
G. D. Hutchins
What Is the Best Approach to Quantify Myocardial Blood Flow with PET?
J. Nucl. Med., August 1, 2001; 42(8): 1183 - 1184.
[Full Text] [PDF]

Home page
 CirculationHome page
F. M. Bengel, P. Ueberfuhr, N. Schiepel, S. G. Nekolla, B. Reichart, and M. Schwaiger
Myocardial Efficiency and Sympathetic Reinnervation After Orthotopic Heart Transplantation : A Noninvasive Study With Positron Emission Tomography
Circulation, April 10, 2001; 103(14): 1881 - 1886.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
A. F. Maes, F. Van de Werf, L. V. Mesotten, P. B. Flamen, R. S. Kuzo, J. L. Nuyts, and L. Mortelmans
Early assessment of regional myocardial blood flow and metabolism in thrombolysis in myocardial infarction flow grade 3 reperfused myocardial infarction using carbon-11-acetate
J. Am. Coll. Cardiol., January 1, 2001; 37(1): 30 - 36.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
R. R. Sciacca, O. Akinboboye, R. Ling Chou, S. Epstein, and S. R. Bergmann
Measurement of Myocardial Blood Flow with PET Using 1-11C-Acetate
J. Nucl. Med., January 1, 2001; 42(1): 63 - 70.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
S.-T. Li, C. J. Tack, L. Fananapazir, and D. S. Goldstein
Myocardial perfusion and sympathetic innervation in patients with hypertrophic cardiomyopathy
J. Am. Coll. Cardiol., June 1, 2000; 35(7): 1867 - 1873.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
F. M. Bengel, S. G. Nekolla, T. Ibrahim, C. Weniger, S. I. Ziegler, and M. Schwaiger
Effect of Thyroid Hormones on Cardiac Function, Geometry, and Oxidative Metabolism Assessed Noninvasively by Positron Emission Tomography and Magnetic Resonance Imaging
J. Clin. Endocrinol. Metab., May 1, 2000; 85(5): 1822 - 1827.
[Abstract] [Full Text]

Home page
 Eur Heart JHome page
A. L'Abbate, G. Sambuceti, S. Haunso, and J. Schneider-Eicke
Methods for evaluating coronary microvasculature in humans
Eur. Heart J., September 2, 1999; 20(18): 1300 - 1313.
[PDF]

Home page
 CirculationHome page
F. M. Bengel, P. Ueberfuhr, S. I. Ziegler, S. Nekolla, B. Reichart, and M. Schwaiger
Serial Assessment of Sympathetic Reinnervation After Orthotopic Heart Transplantation : A Longitudinal Study Using PET and C-11 Hydroxyephedrine
Circulation, April 13, 1999; 99(14): 1866 - 1871.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
H. Schoder, R. Campisi, T. Ohtake, C. K. Hoh, D. H. Moon, J. Czernin, and H. R. Schelbert
Blood flow-metabolism imaging with positron emission tomography in patients with diabetes mellitus for the assessment of reversible left ventricular contractile dysfunction
J. Am. Coll. Cardiol., April 1, 1999; 33(5): 1328 - 1337.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
H. G. Wolpers, W. Burchert, J. van den Hoff, R. Weinhardt, G.-J. Meyer, and P. R. Lichtlen
Assessment of Myocardial Viability by Use of 11C-Acetate and Positron Emission Tomography : Threshold Criteria of Reversible Dysfunction
Circulation, March 18, 1997; 95(6): 1417 - 1424.
[Abstract] [Full Text]

Home page
 CirculationHome page
T. Hata, R. Nohara, M. Fujita, R. Hosokawa, L. Lee, T. Kudo, E. Tadamura, N. Tamaki, J. Konishi, and S. Sasayama
Noninvasive Assessment of Myocardial Viability by Positron Emission Tomography With 11C Acetate in Patients With Old Myocardial Infarction: Usefulness of Low-Dose Dobutamine Infusion
Circulation, October 15, 1996; 94(8): 1834 - 1841.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH RSS TABLE OF CONTENTS
JOURNAL OF NUCLEAR MEDICINE TECHNOLOGY THE JOURNAL OF NUCLEAR MEDICINE
Copyright © 1991 by the Society of Nuclear Medicine.