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The Localization of Indium-111-Leukocytes, Gallium-67-Polyclonal IgG and Other Radioactive Agents in Acute Focal Inflammatory Lesions

Divisions of Nuclear Medicine and Radiological Sciences, Department of Radiology, SUNY Health Sciences Center, Syracuse, New York

Correspondence: For reprints contact: John G. McAfee, MD, Division of Nuclear Medicine, Department of Radiology, The George Washington University Hospital, 901 23rd St., N.W., Washington, DC 20037.

ABSTRACT

A variety of radioactive agents, injected directly intravenously have demonstrated foci of inflammation by gamma camera imaging, avoiding the in vitro preparation of labeled leukocytes. This study sought to find out if any of these agents mimicked the biodistribution in abscesses and non-target organs of labeled mixed leukocyte suspensions. Eight different agents were compared with ¹¹¹In-oxine labeled leukocytes in an acute soft tissue E. coli abscess and an acute arthritic lesion in 24 dogs one day after intravenous administration. These included ⁶⁷Ga-citrate, human and canine polyclonal immunoglobulin (IgG), rabbit anti-dog polyclonal IgG, serum albumin, monoclonal antibody TNT-1 F(ab')₂ against nuclear antigens, ⁵⁷Co-porphyrin and serum albumin nanocolloid. None of these agents achieved abscess concentrations approaching those obtained with labeled leukocytes, and their abscess/blood and abscess/muscle concentration ratios were considerably lower. No statistically significant differences were found between the different radiolabeled proteins evaluated. The abscess concentration of ^99mTc-nanocolloid was much lower than that of other agents, and the results with the oldest agent, ⁶⁷Ga-citrate, were disappointing in these acute experiments.