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Technetium-99m-MAG₃ Versus Iodine-123-OIH: Renal Clearance and Distribution Volume as Measured by a Constant Infusion Technique

Department of Nuclear Medicine, University Hospital Utrecht, Heidelberglaan, Utrecht, The Netherlands

Correspondence: For reprints contact: J.A.C. Prenen, MD, PhD, Dept. of Nuclear Medicine, St. Franciscus Ziekenhuis, Boerhaavelaan 25, 4708 AE Roosendaal, The Netherlands.

ABSTRACT

The renal clearance and distribution volume of ^99mTc-mercaptoacetyltriglycine (MAG₃) and ¹²³I-o-iodohippurate (OIH) were determined separately in six normal male volunteers using the constant infusion clearance technique in order to validate single injection clearance techniques and subsequently the normal values for these parameters. MAG₃ renal clearance was 257 ± 24 ml/min/1.73 m², compared to the OIH clearance of 556 ± 46 ml/min/1.73 m² resulting in a MAG₃/OIH clearance ratio of 0.47 ± 0.06. The MAG₃ and OIH apparent distribution volumes at steady-state were 14.8 ± 3.7 and 19.4 ± 5.3 liters, respectively, the latter value approximating the extra cellular fluid volume. Urinary excretion in the 0–30-min period after intravenous administration was 64.4 and 70.2% for MAG₃ and OIH, respectively. This investigation revealed some significant differences in the normal values of the renal clearance and distribution volume of MAG₃ compared with other studies.

FOOTNOTES

^* Present address: Department of Nuclear Medicine, St. Franciscus Ziekenhuis, Boerhaavelaan 25, 4708 AE Roosendaal, The Netherlands.