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Noninvasive Delineation of the Effects of Moderate Aging on Myocardial Perfusion

Cardiovascular Division, Washington University School of Medicine, St. Louis, Missouri

Correspondence: For reprints contact: Martha J. Senneff, MD, Cardiovascular Division, Washington University School of Medicine, Box 8086, 660 S. Euclid Ave., St. Louis, MO 63110.

ABSTRACT

Aging is accompanied by a decline in many aspects of cardiovascular function but little is known regarding its influence on myocardial perfusion. Eleven young adults (mean age 25 ± 4 (s.d.) yr) and 15 older adults (mean age 55 ± 9 yr) without history or symptoms of cardiovascular disease were studied using H₂¹⁵O and positron emission tomography under resting conditions and following administration of intravenous dipyridamole. Myocardial perfusion at rest was similar in the older and younger subjects, averaging 1.17 ± 0.35 and 1.16 ± 0.32 ml/g/min, respectively (p = ns). Following dipyridamole, peak myocardial perfusion was blunted in the older subjects, averaging 3.12 ± 1.09 ml/g/min compared with 4.25 ± 1.54 ml/g/min in the young adults (p=0.044). Accordingly, present standards for normal perfusion responses to intravenous dipyridamole may require adjustment for age.

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