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Detection of Subacute Infectious Foci with Indium-111-Labeled Autologous Leukocytes and Indium-111-Labeled Human Nonspecific Immunoglobulin G: A Prospective Comparative Study

Departments of Nuclear Medicine and Internal Medicine, Division of General Internal Medicine, University Hospital Nijmegen, University of Nijmegen, The Netherlands

Correspondence: For reprints contact: Wim J. G. Oyen, MD, Department of Nuclear Medicine, University Hospital Nijmegen, P. O. Box 9101, 6500 HB Nijmegen, The Netherlands.

ABSTRACT

In 35 patients suspected of an infectious focus, the outcome of scintigraphy with ¹¹¹In-labeled autologous leukocytes (WBC) and ¹¹¹In-labeled human nonspecific immunoglobulin G (IgG) was evaluated in a prospective comparative study. Clinical, roentgenologic and microbiologic findings were considered to be proof of the presence of infection or inflammation. In this group of patients with mainly subacute infections, ¹¹¹In-IgG scintigraphy performed significantly better than ¹¹¹In-WBC scintigraphy, especially in infections of the locomotor system, but also in various soft-tissue infections. Both techniques showed disappointing results in patients with dissemmated yersinia infection and in some patients with tuberculosis. Overall sensitivity and specificity was 74% and 100% for ¹¹¹In-IgG scintigraphy and 52% and 78% for ¹¹¹In-WBC scintigraphy, respectively.

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