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Sensitivity of Measurements of Regional Brain Activation with Oxygen-15-Water and PET to Time of Stimulation and Period of Image Reconstruction

Medical Department and Chemistry Department, Brookhaven National Laboratory, Upton, New York
Department of Psychiatry, SUNY at Stony Brook, Stony Brook, New York
Division of Cardiology, University of Texas Health Science Center, Houston, Texas

Correspondence: For reprints contact: Nora D. Volkow, MD, Medical Department Brookhaven National Laboratory, Upton, NY 11973.

ABSTRACT

Measurement of oxygen-15-(¹⁵O) water uptake with positron emission tomography (PET) is a sensitive technique to monitor regional brain activation secondary to stimulation paradigms. In order to investigate data acquisition times that show maximal changes in regional activation and to assess the optimal time for stimulus presentation, we investigated 10 controls with ¹⁵O-water and PET during baseline and stroboscopic light stimulation. Sequential scans were done varying the time of stimulus presentation. The images were reconstructed using three different periods of data acquisition: uptake phase (initial 30–35 sec), washout phase (40 sec following peak activity in brain), and total activity (3 min). The images reconstructed during the uptake phase showed the largest changes in occipital cortex from stimulation. Maximal changes in occipital cortex were obtained when the visual stimulus was maintained during the uptake phase only.

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