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A Model of Gastric Emptying in Cats Shows Solid Emptying is Promoted by MK-329: A CCK Antagonist

Departments of Pharmacology and Research Imaging, Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania

Correspondence: For reprints contact: Howard F. Solomon, PhD, Merck Sharp & Dohme Research Laboratories, West Point, PA 19486.

ABSTRACT

The effect of MK-329, a potent, orally active, nonpeptidal cholecystokinin (CCK) antagonist, was measured on the gastric emptying rate of a solid meal in cats. External scintigraphy of cats that had been fed a meal of technetium-99m- (^99mTc) labeled rabbit liver and light cream allowed the measurement of the emptying rates of either the liquid or solid portion of a meal under physiologic conditions. In cats, liquids emptied 2.6 times faster than solids [163 ± 11 min vs. 62 ± 3 min (mean ± s.e.)]. At 3 or 10 mg/kg p.o., MK-329 gastric emptying was significantly accelerated, with the mean half-time of emptying being decreased by 34 ± 11% (mean ± s.e.) of the control half-times (p <0.02). Using only responders (five of six animals), mean half-time was decreased by 55 ± 4% of the control half-times. CCK is important in regulating the emptying of solid food from the stomach because the CCK antagonist MK-329 accelerates that emptying.

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