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Serum Osteocalcin Measurements in Prostate Carcinoma Patients with Skeletal Deposits Shown by Bone Scintigram: Comparison with Serum PSA/PAP Measurements

Nuclear Medicine Service, VA and University of Kentucky Medical Centers, Lexington, Kentucky and Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio

Correspondence: For reprints contact: Dr. Wei-Jen Shih, Nuclear Medicine Service, University of Kentucky Medical Center, Lexington, KY 40536.

ABSTRACT

The correlation of technetium-99m-HMDP bone scintigraphic findings, serum osteocalcin as a measure of bone turnover and prostate-specific antigen (PSA) and/or prostate acid phosphatase (PAP) was determined in 19 men with bone metastasis due to prostatic carcinoma. Six of the 19 patients with metastases on bones can showed elevation of osteocalcin. These patients had extensive metastatic disease. All 19 men with positive bone scans had high serum PSA and/or PAP levels. Serum osteocalcin measurement is less sensitive to detection of bone deposits than PSA/PAP measurements (p<0.0008).

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