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McCune-Albright Syndrome: The Patterns of Scintigraphic Abnormalities

Department of Nuclear Medicine and the Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland

Correspondence: For reprints contact: Theodore R. Simon, MD, Building 10, Room 1C401, Warren G. Magnuson Clinical Center, Department of Nuclear Medicine, 9000 Rockville Pike, Bethesda, MD 20892.

ABSTRACT

This study of 22 patients with the McCune-Albright syndrome examined the scintigraphic distribution of fibrous dysplasia. The most frequently affected areas were the base of the skull(82% of patients), mandible (50%), facial bones (45%), femora (59%), and legs (64%). The least frequently affected areas included the hands (none), wrists (none), ankles (none), feet (5%), sacrum (5%), and vertebrae (9%). The distribution varied somewhat from idiopathic fibrous dysplasia but generally agreed with the distributions reported in radiographic studies of patients with the McCune-Albright Syndrome. The serum alkaline phosphatase was not an accurate predictor of the extent of fibrous dysplasia.

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